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Current Topics in Microbiology and Immunology: Ergebnisse Der Mikrobiologie Und Immunitätsforschung
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Series: Current Topics in Microbiology and Immmunology, Book 45
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ISBN10: 3642501117
ISBN13: 9783642501111
Publisher: Springer
Published: May 19 2012
Pages: 238
Weight: 0.87
Height: 0.51 Width: 6.69 Depth: 9.61
Language: English
ISBN13: 9783642501111
Publisher: Springer
Published: May 19 2012
Pages: 238
Weight: 0.87
Height: 0.51 Width: 6.69 Depth: 9.61
Language: English
In lymphoiden Zellen Tb-sensibilisierter Meerschweinchen sind sessile Antikörper vorhanden, die in der Lage sind nach Kontakt mit Tuberkulin Komplement zu binden. Dieser Nachweis ist sowohl fluorescenzserologisch als auch - unter Verwendung von Extrakten aus solchen Zellen - mit der Hämagglutination und der Coombs-Technik oder mit dem Konglutinations- verfahren möglich. Sie können ferner mit dem Hämaggregationsverfahren nachgewiesen werden. Die sessilen Antikörper besitzen mindestens zwei, nach ihrer immunologischen Spezifität und dem Mechanismus ihrer cytolytischen Funktion distinkte immunologische Spezifitäten. Die eine ist gegen den Haupt- bestandteil von Alttuberkulin (Tuberkulopolysaccharide) und die andere gegen den von gereinigtem Tuberkulin (Tuberkuloproteine) gerichtet. Beide Anti- körper können auf wei e Zellen nicht sensibilisierter Tiere übertragen werden. Sie sind mercaptoäthanolempfindlich und können deswegen den Antikörpern vom 19 S-Typ zugerechnet werden. Sie sind nicht identisch mit den cytophilen Antikörpern; auch scheint keine direkte kausale Beziehung zur Tuberkulin- Hautreaktion zu bestehen. Ihre mögliche Bedeutung wird diskutiert. Lymphoide Zellen von Tb-sensibilisierten Meerschweinchen enthalten au erdem noch einen Faktor, der in vitro Agglutinationsreaktion und in vivo PCA-Reaktionen hemmt. Literatur BAlL, 0.: Übertragung der Tuberkulinempfindliehkeit. Z. Immun.-Forseh. 1. Orig. 4,470 (1910). BLAZKOVEC, A. A., E. SORKIN, and J. L. TURK: A study of the passive eellular transfer of loeal eutaneous hypersensitivity. Int. Areh. Allergy 27, 289 (1965). BLOOM, B. R., and B. BENNETT: Meehanism of areaction in vitra associated with delayed type hypersensitivity. Scienee 153, 80 (1966). - - Delayed hypersensitivity in vitra: the meehanism of inhibition by antigen of eell migration. Fed. Prae. 25, 355 (1966).
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Current Topics in Microbiology and Immunology: Ergebnisse Der Mikrobiologie Und Immunitätsforschung
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