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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
A Comparative Study on the Effect of Integrin Subunits Beta One and Beta Three on Osteoblast Implant Interactions.

A Comparative Study on the Effect of Integrin Subunits Beta One and Beta Three on Osteoblast Implant Interactions.

Duqum, Ibrahim

Paperback

Biology

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ISBN10: 1243441445
ISBN13: 9781243441447
Publisher: Proquest Umi Dissertation Pub
Pages: 114
Weight: 0.53
Height: 0.30 Width: 7.99 Depth: 10.00
Language: English
Background. Integrin transmembrane receptors has emerged as central regulators of cell biomaterial interactions. Aim. To explore the effects of integrin beta1 and beta3 receptors on osteoblast implant surface interactions in vitro. Materials and methods. Specific monoclonal antibodies were used to functionally perturb the respective integrin receptors before cell plating on CpTi disks of two distinct surface topographies. RT2 Profiler(TM)PCR Arrays system, quantified the expression of a panel of osteogenesis related genes. Moreover, scanning electron microscopy was used to evaluate the effects of integrin functional perturbation on initial cell adhesion and spreading, in a surface and time dependent manner. Results. Data from both morphological and molecular studies showed that functional perturbation of both integrin subunits, significantly affected initial cell adhesion, spreading, and osteogenesis related gene expression, in a surface dependent manner. Conclusion. Integrin beta1 and beta3 are involved in initial osteoblast adhesion and spreading on implant surface. Moreover, they mediate implant surface specific changes.

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