Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Clinical Neonatal Pharmacology: Physiology, Dosing, And Safe Practice

Clinical Neonatal Pharmacology: Physiology, Dosing, And Safe Practice

Paperback

Medical Reference

Currently unavailable to order

ISBN13: 9798170166558
Publisher: Independently Published
Pages: 234
Weight: 1.22
Height: 0.49 Width: 8.50 Depth: 11.00
Language: English
Clinical Neonatal Pharmacology: Physiology, Dosing, And Safe Practice confronts the critical, often life-or-death, principle that the pediatric patient is not merely a smaller adult. This foundational text dismantles the dangerously persistent myth of simply scaling adult doses, revealing a specialized pharmacological landscape demanding scientific rigor and profound empathy. Neonates are developing organisms whose systems are in constant flux, making every calculation, administration, and monitoring parameter distinct. The stakes are undeniably higher, as a single medication error or an inappropriately managed drug regimen can irrevocably alter a neonate's developmental trajectory.

This comprehensive guide delves into the inherent physiological differences that profoundly influence drug pharmacokinetics (PK) and pharmacodynamics (PD). It meticulously explores unique challenges posed by varying body compositions, such as the neonate's higher total body water impacting drug distribution, and the implications of lower body fat for lipophilic medications. A crucial focus is placed on plasma protein binding, where lower albumin and increased competition for binding sites can lead to significantly elevated free drug levels and heightened toxicity risks, as tragically demonstrated by historical events like kernicterus.

Beyond theoretical understanding, Clinical Neonatal Pharmacology provides practical, actionable insights for safe and effective practice. It moves from mastering precision dosing calculations and drug preparation to navigating administration methodologies and implementing vigilant patient monitoring. The book offers a proactive stance on unveiling drug interactions and adverse events, alongside detailed guidance on condition-specific therapies tailored to the unique needs of the premature infant and other neonatal populations. It also covers critical interventions, including antidotes, weaning protocols, and factors influencing drug effectiveness like bioavailability.

For any healthcare professional involved in neonatal care-including neonatologists, pediatricians, pharmacists, advanced practice nurses, and residents-this book is an indispensable resource. It equips practitioners with essential knowledge and consultation strategies needed to navigate the complexities of neonatal pharmacotherapy, ensuring the highest standards of patient safety and optimal outcomes.

Key aspects of this essential resource include:

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