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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Chromosomal Translocations and Oncogenic Transcription Factors

Chromosomal Translocations and Oncogenic Transcription Factors

Rauscher, Frank J. III
Vogt, Peter K.

Paperback

Series: Current Topics in Microbiology and Immmunology, Book 220

Biographies GeneralMedical ReferenceBiology

ISBN10: 3642644244
ISBN13: 9783642644245
Publisher: Springer
Published: Oct 2 2011
Pages: 166
Weight: 0.59
Height: 0.39 Width: 6.14 Depth: 9.21
Language: English
Regulation of gene expression at the level of transcription is one of the major determinants of proper cellular proliferation and differentiation. The key players in these processes are sequence-specific DNA binding transcription factor proteins which coordinate programs of gene expression in the nucleus. The articles in this volume document the myriad of genetic and biochemical alterations sustained by human proto-oncogenic transcription factors which result in diverse neoplastic processes. This volume gives insights into how normal programs of gene expression can be subverted by the action of single transcription factors resulting in a specific tumor type. The book provides inspiration for exploiting these tumor-specific alterations as diagnostic, prognostic tools, or as selective therapeutic targets.

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