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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Chloride Channels and Carriers in Nerve, Muscle, and Glial Cells

Chloride Channels and Carriers in Nerve, Muscle, and Glial Cells

Alvarez-Leefmans, F. J.
Russell, John M.

Hardcover

Medical ReferenceBiologyCognition

ISBN10: 0306434261
ISBN13: 9780306434266
Publisher: Springer
Published: May 31 1990
Pages: 426
Weight: 2.18
Height: 1.00 Width: 7.00 Depth: 10.00
Language: English
This is a book about how Cl- crosses the cell membranes of nerve, muscle, and glial cells. Not so very many years ago, a pamphlet rather than book might have resulted from such an endeavor! One might ask why Cl-, the most abundant biological anion, attracted so little attention from investigators. The main reason was that the prevailing paradigm for cellular ion homeostasis in the 1950s and 1960s assigned Cl- a ther- modynamically passive and unspecialized role. This view was particularly prominent among muscle and neuroscience investigators. In searching for reasons for such a negative (no pun intended) viewpoint, it seems to us that it stemmed from two key experimental observations. First, work on frog skeletal muscle showed that Cl- was passively distributed between the cytoplasm and the extracellular fluid. Second, work on Cl- transport in red blood cells confirmed that the Cl- transmembrane distribution was thermodynamically passive and, in addition, showed that Cl- crossed the mem- brane extremely rapidly. This latter finding [for a long time interpreted as being the result of a high passive chloride electrical permeability(? CI)] made it quite likely that Cl- would remain at thermodynamic equilibrium. These two observations were gener- alized and virtually all cells were thought to have a very high P Cl and a ther- modynamically passive Cl- transmembrane distribution. These concepts can still be found in some physiology and neuroscience textbooks.

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