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Characterization of Nanoparticles Intended for Drug Delivery
Paperback
Series: Methods in Molecular Biology, Book 1682
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ISBN10: 1493984608
ISBN13: 9781493984602
Publisher: Humana
Published: May 18 2018
Pages: 256
Weight: 1.09
Height: 0.57 Width: 9.96 Depth: 7.05
Language: English
ISBN13: 9781493984602
Publisher: Humana
Published: May 18 2018
Pages: 256
Weight: 1.09
Height: 0.57 Width: 9.96 Depth: 7.05
Language: English
PrefaceTable of Contents...Contributing Authors...
Part I Introduction 1. Evaluating Nanomedicines: Obstacles and AdvancementsMagdalena Swierczewska, Rachael M. Crist, and Scott E. McNeil
Part II Sterility and Endotoxin Testing
2. Detection of Bacterial Contamination in Nanoparticle Formulations by Agar Plate TestTimothy M. Potter, Barry W. Neun, Anna N. Ilinskaya, and Marina A. Dobrovolskaia
Part I Introduction 1. Evaluating Nanomedicines: Obstacles and AdvancementsMagdalena Swierczewska, Rachael M. Crist, and Scott E. McNeil
Part II Sterility and Endotoxin Testing
2. Detection of Bacterial Contamination in Nanoparticle Formulations by Agar Plate TestTimothy M. Potter, Barry W. Neun, Anna N. Ilinskaya, and Marina A. Dobrovolskaia
3. Considerations and Some Practical Solutions to Overcome Nanoparticle Interference with LAL Assays and to Avoid Endotoxin Contamination in NanoformulationsBarry W. Neun and Marina A. Dobrovolskaia
Part III Physicochemical Characterization
4. Elemental Analysis in Biological Matrices Using ICP-MSMatthew N. Hansen and Jeffrey D. Clogston
5. PEG Quantitation Using Reversed Phase High Performance Liquid Chromatography and Charged Aerosol DetectionMackensie C. Smith and Jeffrey D. Clogston
6. Quantitation of Surface Coating on Nanoparticles Using Thermogravimetric AnalysisAlpana A. Dongargaonkar and Jeffrey D. Clogston
7. Immunoelectron Microscopy for Visualization of NanoparticlesSarah R. Anderson, David Parmiter, Ulrich Baxa, and Kunio Nagashima
8. Imaging of Liposomes by Transmission Electron MicroscopyUlrich Baxa
Part IV Immunology
9. Updated Method for In Vitro Analysis of Nanoparticle Hemolytic PropertiesBarry W. Neun, Anna N. Ilinskaya, and Marina A. Dobrovolskaia
10. In Vitro Assessment of Nanoparticle Effects on Blood CoagulationTimothy M. Potter, Jamie C. Rodriguez, Barry W. Neun, Anna N. Ilinskaya, Edward Cedrone, and Marina A. Dobrovolskaia
11. In Vitro Analysis of Nanoparticle Effects on the Zymosan Uptake by Phagocytic CellsTimothy M. Potter, Sarah L. Skoczen, Jamie C. Rodriguez, Barry W. Neun, Anna N. Ilinskaya, Edward Cedrone, and Marina A. Dobrovolskaia
12. Assessing NLRP3 Inflammasome Activation by NanoparticlesBhawna Sharma, Christopher B. McLeland, Timothy M. Potter, Stephan T. Stern, and Pavan P. Adiseshaiah
13. Analysis of Complement Activation by NanoparticlesBarry W. Neun, Anna A. Ilinskaya, and Marina A. Dobrovolskaia
14. Methods for Analysis of Nanoparticle Immunosuppressive Properties In Vitro and In VivoTimothy M. Potter, Barry W. Neun, and Marina A. Dobrovolskaia
15. Analysis of Pro-Inflammatory Cytokine and Type II Interferon Induction by NanoparticlesTimothy M. Potter, Barry W. Neun, Jamie C. Rodriguez, Anna N. Ilinskaya, and Marina A. Dobrovolskaia 16. Analysis of Nanoparticle Adjuvant Properties In VivoBarry W. Neun and Marina A. Dobrovolskaia
17. In Vitro and In Vivo Methods for Analysis of Nanoparticle Potential to Induce Delayed Type Hypersensitivity ReactionsTimothy M. Potter, Barry W. Neun, and Marina A. Dobrovolskaia
18. Autophagy Monitoring Assay II: Imaging Autophagy Induction in LLC-PK1 Cells Using GFP-LC3 Protein Fusion ConstructPavan P. Adiseshaiah, Sarah L. Skoczen, Jamie C. Rodriguez, Timothy M. Potter, Krishna Kota, and Stephan T. Stern
Part V Drug Release and In Vivo Efficacy
19. Improved Ultrafiltration Method to Measure Drug Release from Nanomedicines Utilizing a Stable Isotope TracerSarah L. Skoczen and Stephan T. Stern
20. Designing an In Vivo Efficacy Study of Nanomedicines for Preclinical Tumor Growth InhibitionPavan P. Adiseshaiah and Stephan T. Stern
Part III Physicochemical Characterization
4. Elemental Analysis in Biological Matrices Using ICP-MSMatthew N. Hansen and Jeffrey D. Clogston
5. PEG Quantitation Using Reversed Phase High Performance Liquid Chromatography and Charged Aerosol DetectionMackensie C. Smith and Jeffrey D. Clogston
6. Quantitation of Surface Coating on Nanoparticles Using Thermogravimetric AnalysisAlpana A. Dongargaonkar and Jeffrey D. Clogston
7. Immunoelectron Microscopy for Visualization of NanoparticlesSarah R. Anderson, David Parmiter, Ulrich Baxa, and Kunio Nagashima
8. Imaging of Liposomes by Transmission Electron MicroscopyUlrich Baxa
Part IV Immunology
9. Updated Method for In Vitro Analysis of Nanoparticle Hemolytic PropertiesBarry W. Neun, Anna N. Ilinskaya, and Marina A. Dobrovolskaia
10. In Vitro Assessment of Nanoparticle Effects on Blood CoagulationTimothy M. Potter, Jamie C. Rodriguez, Barry W. Neun, Anna N. Ilinskaya, Edward Cedrone, and Marina A. Dobrovolskaia
11. In Vitro Analysis of Nanoparticle Effects on the Zymosan Uptake by Phagocytic CellsTimothy M. Potter, Sarah L. Skoczen, Jamie C. Rodriguez, Barry W. Neun, Anna N. Ilinskaya, Edward Cedrone, and Marina A. Dobrovolskaia
12. Assessing NLRP3 Inflammasome Activation by NanoparticlesBhawna Sharma, Christopher B. McLeland, Timothy M. Potter, Stephan T. Stern, and Pavan P. Adiseshaiah
13. Analysis of Complement Activation by NanoparticlesBarry W. Neun, Anna A. Ilinskaya, and Marina A. Dobrovolskaia
14. Methods for Analysis of Nanoparticle Immunosuppressive Properties In Vitro and In VivoTimothy M. Potter, Barry W. Neun, and Marina A. Dobrovolskaia
15. Analysis of Pro-Inflammatory Cytokine and Type II Interferon Induction by NanoparticlesTimothy M. Potter, Barry W. Neun, Jamie C. Rodriguez, Anna N. Ilinskaya, and Marina A. Dobrovolskaia 16. Analysis of Nanoparticle Adjuvant Properties In VivoBarry W. Neun and Marina A. Dobrovolskaia
17. In Vitro and In Vivo Methods for Analysis of Nanoparticle Potential to Induce Delayed Type Hypersensitivity ReactionsTimothy M. Potter, Barry W. Neun, and Marina A. Dobrovolskaia
18. Autophagy Monitoring Assay II: Imaging Autophagy Induction in LLC-PK1 Cells Using GFP-LC3 Protein Fusion ConstructPavan P. Adiseshaiah, Sarah L. Skoczen, Jamie C. Rodriguez, Timothy M. Potter, Krishna Kota, and Stephan T. Stern
Part V Drug Release and In Vivo Efficacy
19. Improved Ultrafiltration Method to Measure Drug Release from Nanomedicines Utilizing a Stable Isotope TracerSarah L. Skoczen and Stephan T. Stern
20. Designing an In Vivo Efficacy Study of Nanomedicines for Preclinical Tumor Growth InhibitionPavan P. Adiseshaiah and Stephan T. Stern
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