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The Base Excision Repair Pathway

The Base Excision Repair Pathway

Hardcover

Medical ReferenceBiology

ISBN10: 9814719722
ISBN13: 9789814719728
Publisher: World Scientific Publishing Company
Published: Feb 9 2017
Pages: 824
Weight: 3.20
Height: 1.60 Width: 6.30 Depth: 9.10
Language: English

This book will serve as the preeminent text book on the topic of base excision repair, a key DNA repair pathway that protects cells from most spontaneous forms of DNA damage, including oxidative lesions that arise both in the nuclear and mitochondrial genomes. The book, which includes contributions from many of the world leaders in the field, provides a detailed description of the molecular mechanisms of base excision repair, as well as its emerging relationship to epigenetic regulation, the aging process and human disease, such as cancer susceptibility, immunological defects and neurological disorders. The book will also cover the state-of-the-art technologies being developed to assess base excision repair capacity among individuals in the population, in addition to the strategies being employed to target base excision repair as part of therapeutic paradigms to eradicate disease, namely cancer.

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