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Bace: Lead Target for Orchestrated Therapy of Alzheimer's Disease
Hardcover
ISBN13: 9780470293423
Publisher: Wiley
Published: Mar 15 2010
Pages: 266
Weight: 1.10
Height: 0.70 Width: 6.30 Depth: 9.30
Language: English
BACE inhibitors and their use in the treatment of Alzheimer's Disease
BACE (β-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery.
This book details the story of the discovery of BACE and its role in AD and comprehensively discusses:
- The development of BACE inhibitors as therapeutics for Alzheimer's disease
- The research that led to the identification of BACE
- New BACE inhibitors currently being clinically tested
- ADME (absorption, distribution, metabolism, excretion) and clinical trial design--topics not addressed in current field literature
- Cutting-edge technology such as high-throughput screening, structure-based drug design, and QSAR in context of BACE inhibitors and Alzheimer's drug discovery
- Other approaches to BACE inhibition based on interaction with the precursor protein APP
By enhancing the reader's understanding of the various aspects of the BACE drug-discovery process, this much-needed reference will serve as a key resource for all scientists involved in Alzheimer's research--and inspire new approaches to treatment of AD.
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