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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
B Cell Receptor Signaling

B Cell Receptor Signaling

Wienands, Jürgen
Kurosaki, Tomohiro

Paperback

Series: Current Topics in Microbiology and Immmunology, Book 393

Medical ReferenceBiology

ISBN10: 3319798995
ISBN13: 9783319798998
Publisher: Springer
Published: Mar 30 2018
Pages: 231
Weight: 0.76
Height: 0.51 Width: 6.14 Depth: 9.21
Language: English

This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton's Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, whilealso paving the way for eventually combating these diseases.

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