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Arachidonate Remodeling and Inflammation
Paperback
Series: Progress in Inflammation Research
ISBN13: 9783034895941
Publisher: Springer Nature
Published: Oct 21 2012
Pages: 243
Weight: 0.81
Height: 0.55 Width: 6.14 Depth: 9.21
Language: English
Arachidonic acid (AA) and other 20 or 22-carbon polyunsaturated fatty acids (PUFAs) are precursors of lipid mediators of inflammation known as eicosanoids. These mediators are critical in disease processes and in regulating normal cell function. Remodeling is important in maintaining homeostasis and in regulating cell function by dictating how PUFAs are converted to lipid mediators of inflammation. Thus, PUFA remodeling is a critical process in the biosynthesis of a multitude of mediators, and understanding this process will unravel better therapeutic targets for controlling inflammatory diseases such as asthma and Alzheimer's disease.
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