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Antibody-Drug Conjugates
Paperback
Series: Methods in Molecular Biology, Book 1045
ISBN13: 9781493960262
Publisher: Humana Pr
Published: Aug 23 2016
Pages: 317
Weight: 1.26
Height: 0.69 Width: 7.00 Depth: 10.00
Language: English
1. Antibody-Drug Conjugate (ADC) Clinical Pipeline: A Review
Ingrid Sassoon and Véronique Blanc
2. Antibody-Drug Conjugate Target Selection: Critical Factors
Neil H. Bander
3. Selecting an Optimal Antibody for Antibody-Drug Conjugate Therapy: Internalization and Intracellular Localization
Jay Harper, Shenlan Mao, Patrick Strout, and Adeela Kamal
4. Antibody-Drug Conjugate Payloads
Jan Anderl, Heinz Faulstich, Torsten Hechler and Michael Kulke
5. Linker Technologies for Antibody-Drug Conjugates
Birte Nolting
6. In Vivo Testing of Drug-Linker Stability
Pierre-Yves Abecassis and Céline Amara
7. Pharmacokinetics and ADME Characterizations of Antibody-Drug Conjugates
Kedan Lin, Jay Tibbitts, and Ben-Quan Shen
8. Safe Handling of Cytotoxic Compounds in a Biopharmaceutical Environment
Miriam I. Hensgen and Bernhard Stump
9. Micro- and Mid-Scale Maleimide-Based Conjugation of Cytotoxic Drugs to Antibody Hinge Region Thiols for Tumor Targeting
James E. Stefano, Michelle Busch, Lihui Hou, Anna Park, and Diego A. Gianolio
10. Protocols for Lysine Conjugation
Marie-Priscille Brun and Laurence Gauzy-Lazo
11. Engineering THIOMABs for Site-Specific Conjugation of Thiol-Reactive Linkers
Sunil Bhakta, Helga Raab, and Jagath R. Junutula
12. Enzymatic Antibody Modification by Bacterial Transglutaminase
Patrick Dennler, Roger Schibli, and Eliane Fischer
13. Formulation Development of Antibody-Drug Conjugates
William J. Galush and Aditya A. Wakankar
14. Conjugation Process Development and Scale-Up
Bernhard Stump and Jessica Steinmann
15. Methods for Conjugating Antibodies to Nanocarriers
Anil Wagh and Benedict Law
16. Drug-to-Antibody Ratio (DAR) by UV/Vis Spectroscopy
Yan Chen
17. Drug-to-Antibody Ratio (DAR) and Drug Load Distribution by Hydrophobic Interaction Chromatography and Reversed Phase High Performance Liquid Chromatography
Jun Ouyang
18. Drug-to-Antibody Ratio (DAR) and Drug Load Distribution by LC-ESI-MS
Louisette Basa
19. Determination of Charge Heterogeneity and Level of Unconjugated Antibody by Imaged cIEF
Joyce Lin and Alexandru C. Lazar
20. Risk-Based Scientific Approach for Determination of Extractables/Leachables from Biomanufacturing of Antibody-Drug Conjugates (ADCs)
Weibing Ding
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