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Adp-Ribosylation: Metabolic Effects and Regulatory Functions

Adp-Ribosylation: Metabolic Effects and Regulatory Functions

Paperback

Series: Developments in Molecular and Cellular Biochemistry, Book 12

BiologyChemistry

ISBN10: 1461361206
ISBN13: 9781461361206
Publisher: Springer Nature
Published: Oct 12 2012
Pages: 255
Weight: 1.32
Height: 0.55 Width: 8.25 Depth: 11.00
Language: English
Considering the current interest in cellular regulation and intracellular signalling systems, it is surprising that the contribution of ADP-ribosylation reactions to the modulation of a variety of specific cell processes, in parallel with other post-translational modifications such as phosphorylation, has not been generally recognized. While it is not feasible to cover all aspects of ADP-ribosylation, the thirty-one articles contained in this volume provide a valuable overview of recent progress in the field within the context of cell control mechanisms. For the convenience of the reader, the various topics have been grouped into several sections: (a) poly(ADP-ribosyl)ation; (b) mono-ADP-ribosylation; (c) toxin mono-ADP-ribosylation; (d) inhibitors and activators; (e) protein modification with ADP-ribose and its analogues; and (f) non-modification forms of ADP-ribose. The contents of the individual chapters reflect the ideas of the contributors, many of whom have spent their careers attempting to resolve the biological functions of ADP-ribosylation. We hope that this publication will serve as a useful reference for those investigators that are new to the area as well as those who are actively studying ADP-ribosylation.

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