Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Assembly and finalisation of prokaryotic genomes with optical mapping

Assembly and finalisation of prokaryotic genomes with optical mapping

Mariano, Diego C. B.
Ramos, Rommel T. J.
Azevedo, Vasco A. C.

Paperback

Biology

ISBN10: 6209091644
ISBN13: 9786209091643
Publisher: Our Knowledge Publishing
Published: Oct 10 2025
Pages: 56
Weight: 0.19
Height: 0.13 Width: 6.00 Depth: 9.00
Language: English
The constant improvement of DNA sequencing platforms has reduced the time spent on the process of reading and identifying genomes at an increasingly lower cost. However, sequencers still have limitations, such as the size of DNA fragments they are able to identify. Thus, DNA is fragmented before sequencing, and after this step, it is reordered so that it can represent the original genome. This process, known as genome assembly, requires the use of various in vitro and in silico strategies. In recent years, several strategies for genome assembly have been proposed, but there is still no consensus on the best approach. Recently, several genomes have been finalised using a technique known as whole genome optical mapping (WGM). This technique allows for high-quality assemblies from a high-precision restriction map. The restriction map allows contigs to be oriented and ordered without the need for a reference genome. Optical mapping will usher in a new era of faster, lower-cost, and increasingly accurate genome assemblies.

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