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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Application of Solid-State Kinetics to Desolvation Reactions

Application of Solid-State Kinetics to Desolvation Reactions

Khawam, Ammar

Paperback

Medical ReferenceTechnology & Engineering

ISBN10: 3639091140
ISBN13: 9783639091144
Publisher: Blues Kids Of Amer
Published: Nov 19 2008
Pages: 356
Weight: 1.05
Height: 0.74 Width: 6.00 Depth: 9.00
Language: English
The book presents an overview of the solid-state kinetic literature in-cluding methodologies used, mathematical derivations and pharma-ceutical applications. The book investigates the relationship between calculation methods and artifactual results observed in solid-state kinetics. A new approach is proposed for evaluating solid-state kinetic data, this approach combines modelistic and model-free methods in a complimentary manner to achieve consistent kinetic results. Experimental data focused on studying the solid-state stability of several structurally related solvates of sulfameter (5-methoxysulfadiazine), this was done by studying the kinetics of their desolvation reaction both isothermally and nonisothermally. Calculated kinetic parameters were compared and related to the crystal structure of these solvates. A relationship was established between desolvation kinetic parameters (e.g., activation energy) and the solvent size. The solid-state reaction models selected also corresponded to the single crystal structure of the sulfameter-solvate system.

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