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Anticancer Therapeutics: A Clinical Guide to Cancer Pharmacotherapy, Drug Development, Targeted Therapy, Immunotherapy, and Treatment Resistance
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ISBN13: 9798177834221
Publisher: Independently Published
Pages: 828
Weight: 2.39
Height: 1.64 Width: 6.00 Depth: 9.00
Language: English
Publisher: Independently Published
Pages: 828
Weight: 2.39
Height: 1.64 Width: 6.00 Depth: 9.00
Language: English
ANTICANCER THERAPEUTICS A Clinical Guide to Cancer Pharmacotherapy, Drug Development, Targeted Therapy, Immunotherapy, and Treatment Resistance Cancer treatment has evolved from broadly cytotoxic chemotherapy toward increasingly precise approaches guided by tumor biology, molecular characteristics, biomarkers, and mechanisms of treatment response and resistance. ANTICANCER THERAPEUTICS provides a clinically focused overview of the scientific principles and therapeutic strategies that underpin modern cancer pharmacotherapy. This guide examines how anticancer medicines are discovered, developed, evaluated, and applied in clinical practice. It connects fundamental concepts in cancer biology and drug design with the pharmacological principles that influence therapeutic selection, efficacy, toxicity, and resistance. Topics covered include: - Principles of anticancer drug discovery and development
- Molecular mechanisms underlying malignant growth and progression
- Conventional cytotoxic chemotherapy and mechanisms of action
- Hormonal and antihormonal approaches to cancer treatment
- Molecularly targeted therapies and biomarker-driven treatment
- Monoclonal antibodies and other biologic therapeutics
- Immunotherapy and emerging immune-based strategies
- Drug resistance and mechanisms of therapeutic failure
- Combination treatment and strategies for overcoming resistance
- Drug delivery systems designed to improve tumor selectivity
- Liposomal and other advanced drug-delivery technologies
- Antibody- and aptamer-directed therapeutic approaches
- Prodrug strategies and tumor-selective drug activation
- Personalized medicine, pharmacogenetics, and pharmacogenomics
- Emerging approaches in precision oncology and therapeutic development Particular attention is given to the relationship between molecular targets and therapeutic response. Genetic alterations, protein expression, signaling pathways, and other biomarkers can influence both the biology of a tumor and its susceptibility to particular treatments. Understanding these relationships provides an important foundation for selecting therapies and developing more individualized treatment strategies. The book also examines an important challenge in oncology: treatment resistance. Tumors can evolve under therapeutic pressure through genetic and molecular changes, resulting in reduced drug sensitivity or treatment failure. Understanding these mechanisms is essential to the development of rational combination therapies, sequential treatment strategies, and new therapeutic agents. Advanced drug-delivery systems are also explored, including approaches designed to concentrate therapeutic agents within tumors while limiting exposure to healthy tissues. These strategies illustrate how drug design, molecular recognition, pharmacology, and biotechnology increasingly converge in contemporary cancer treatment. Written for readers seeking a clear connection between cancer biology, pharmacology, and therapeutic development, ANTICANCER THERAPEUTICS provides a structured foundation for understanding both established treatment principles and emerging directions in oncology drug development. It is intended as a useful reference for students, healthcare professionals, biomedical scientists, researchers, and readers seeking a clinically oriented introduction to the science and application of modern anticancer therapeutics.
- Conventional cytotoxic chemotherapy and mechanisms of action
- Hormonal and antihormonal approaches to cancer treatment
- Molecularly targeted therapies and biomarker-driven treatment
- Monoclonal antibodies and other biologic therapeutics
- Immunotherapy and emerging immune-based strategies
- Drug resistance and mechanisms of therapeutic failure
- Combination treatment and strategies for overcoming resistance
- Drug delivery systems designed to improve tumor selectivity
- Liposomal and other advanced drug-delivery technologies
- Antibody- and aptamer-directed therapeutic approaches
- Prodrug strategies and tumor-selective drug activation
- Personalized medicine, pharmacogenetics, and pharmacogenomics
- Emerging approaches in precision oncology and therapeutic development Particular attention is given to the relationship between molecular targets and therapeutic response. Genetic alterations, protein expression, signaling pathways, and other biomarkers can influence both the biology of a tumor and its susceptibility to particular treatments. Understanding these relationships provides an important foundation for selecting therapies and developing more individualized treatment strategies. The book also examines an important challenge in oncology: treatment resistance. Tumors can evolve under therapeutic pressure through genetic and molecular changes, resulting in reduced drug sensitivity or treatment failure. Understanding these mechanisms is essential to the development of rational combination therapies, sequential treatment strategies, and new therapeutic agents. Advanced drug-delivery systems are also explored, including approaches designed to concentrate therapeutic agents within tumors while limiting exposure to healthy tissues. These strategies illustrate how drug design, molecular recognition, pharmacology, and biotechnology increasingly converge in contemporary cancer treatment. Written for readers seeking a clear connection between cancer biology, pharmacology, and therapeutic development, ANTICANCER THERAPEUTICS provides a structured foundation for understanding both established treatment principles and emerging directions in oncology drug development. It is intended as a useful reference for students, healthcare professionals, biomedical scientists, researchers, and readers seeking a clinically oriented introduction to the science and application of modern anticancer therapeutics.
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