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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Anti-inflammatory action of the polysaccharide from the alga Hypnea musciformis

Anti-inflammatory action of the polysaccharide from the alga Hypnea musciformis

Vieira de Brito, Tarcisio
Reis Barbosa, André Luiz

Paperback

Medical Reference

ISBN10: 6206813274
ISBN13: 9786206813279
Publisher: Our Knowledge Publishing
Published: Apr 30 2025
Pages: 64
Weight: 0.22
Height: 0.15 Width: 6.00 Depth: 9.00
Language: English
Sulfated polysaccharides extracted from algae have important pharmacological properties. Therefore, the aim of this study was to characterize the sulfated polysaccharide (PLS) from the algae Hypnea musciformis and evaluate its protective effect on colitis induced by trinitrobenzene sulfonic acid in rats. The sulfated polysaccharide has a high molecular mass (1.24 x 105 g.mol-1). The rats were given PLS orally (10, 30 and 60 mg/kg, p.o.). The rats were killed on the third day, the part of the distal colon (5 cm) was excised and the macroscopic scores and wet weight were evaluated. Samples of the intestine were then used for histological evaluation and quantification of glutathione, malonyldehyde acid, myeloperoxidase, nitrate/nitrite and cytokines. Our results show that PLS reduced colitis and all the biochemical parameters analyzed. Thus, we conclude that PLS extracted from the seaweed H. musciformis reduced colitis in the animal model and may have an important promising application in inflammatory bowel diseases.

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