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Animal Models of Neurological Diseases: Experimental Models, Pathology, Behavioral Assessment & Translational Research
Paperback
Publisher: Independently Published
Published: Sep 23 2026
Pages: 560
Weight: 1.63
Height: 1.14 Width: 6.00 Depth: 9.00
Language: English
Animal Models in Neurological Research: From Disease Modeling to Translational Science provides a research-oriented overview of experimental animal models used to investigate neurological and neurodegenerative disorders. Designed for students, researchers, laboratory professionals, and readers interested in preclinical neuroscience, this book explains how different species and disease models are selected, evaluated, validated, and translated toward human research.
The book covers foundational concepts such as construct, face, and predictive validity, model selection, experimental design, behavioral and neurological endpoints, and translational challenges. It examines commonly used models of Alzheimer's disease, Parkinson's disease, stroke, epilepsy, multiple sclerosis, ALS, traumatic brain and spinal cord injury, neuroinflammation, pain, and other neurodegenerative disorders.
Individual chapters discuss transgenic, genetic, toxin-induced, immune-mediated, injury-based, and naturally occurring disease models, including mouse, rat, zebrafish, C. elegans, companion-animal, and non-human primate models. The book also addresses important research considerations including randomization, controls, blinding, sample-size considerations, histopathology, molecular biomarkers, MRI/PET, EEG, reproducibility, pharmacokinetic/pharmacodynamic considerations, animal welfare, and ethical research.
A dedicated focus on model limitations and translational science highlights why findings from animal studies may not always reproduce human disease and why factors such as species, age, sex, genetic background, comorbidities, and experimental design matter.
With a research-focused structure and disease-specific Model Selection Matrix concept, this book serves as a practical reference for understanding how animal models contribute to modern neurological research and where their limitations must be carefully considered.
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