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    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
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Advances in Osteoarthritis

Advances in Osteoarthritis

Tanaka, Seisuke
Hamanishi, Chiaki

Hardcover

Health GeneralMedical Reference

ISBN10: 4431702458
ISBN13: 9784431702450
Publisher: Springer Nature
Published: Dec 1 1998
Pages: 298
Weight: 1.35
Height: 0.75 Width: 6.14 Depth: 9.21
Language: English
Basic research on osteoarthritis has been carried out mainly from the his- tological and biochemical aspects of the degenerating chondrocytes, collagen fibers, and matrix proteoglycans. Undue mechanical stress has been shown to be the principal factor in the initiation of osteoarthritis. Although the exact process by which mechanical stress leads to the total destruction of cartilage tissue remains unclear, several new research methods have enabled us to gain a deeper understanding of the process of degeneration. In October 1997, we organized an international symposium titled Ad- vances in Osteoarthritis in Kobe, with the main topics being updated re- search, diagnosis, and treatment of osteoarthritis. The proceedings of the symposium are presented here in five sections: (1) Mechanical stress and reactions of chondrocytes, such as intracellular ion changes, changes in the cytoskeleton, intracellular messenger systems, release of gas mediators, and changes in electromechanical properties of cartilage; (2) Functional diagnosis of osteoarthritis by MR imaging, and using calpain and collagenase III as new cartilage markers; (3) Treatment with a promising simple washout technique and IL-1RA and MMP antagonists; (4) Cartilage repair by new grafting tech- niques; and (5) Problems following total joint replacement. We sincerely hope that the advanced knowledge provided in this volume of proceedings will be valuable to our readers.

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