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Adenosine Deaminases Acting on RNA (Adars) and A-To-I Editing

Adenosine Deaminases Acting on RNA (Adars) and A-To-I Editing

Hardcover

Series: Current Topics in Microbiology and Immmunology, Book 353

Medical ReferenceBiology

ISBN10: 3642228003
ISBN13: 9783642228001
Publisher: Springer Nature
Published: Nov 6 2011
Pages: 238
Weight: 1.05
Height: 0.90 Width: 6.30 Depth: 9.10
Language: English

The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. It is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property. Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected. Future studies of ADARs no doubt will provide us with additional surprises and new insights into the modulation of biological processes by the ADAR family of proteins.

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