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612-822-4611
Tracing Disease Genes in Non-syndromic Clefts of Orofacial region

Tracing Disease Genes in Non-syndromic Clefts of Orofacial region

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Medical Reference

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ISBN10: 3659688622
ISBN13: 9783659688621
Publisher: Lap Lambert Academic Pub
Published: Mar 31 2015
Pages: 68
Weight: 0.25
Height: 0.16 Width: 6.00 Depth: 9.00
Language: English
Orofacial clefts are major human birth defects with complex etiology. Previous studies have proposed Transforming growth factor - beta 3 (TGF-B3) gene as one of the important genes in which polymorphisms may contribute to nonsyndromic cleft lip and palate, however none of the studies included Indian population. The HLA [Human leucocyte antigen] loci are the most polymorphic human proteins, and by virtue of their extreme polymorphism ensure that few individuals are identical. Hence HLA typing can be used to identify a subset of population who are at an increased risk of developing or inheriting a particular disease or anomaly. Studies pertaining to the relationship of HLA haplotype and cleft lip and palate are very few and none of these includes Indian patients. This study is a pioneering step towards establishing an association of HLA class I genes and TGFB3 gene with cleft lip and palate in patients of Indian origin.

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