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Teratogenicity Testing: Methods and Protocols
Hardcover
Series: Methods in Molecular Biology, Book 1797
ISBN13: 9781493978823
Publisher: Humana Pr
Published: Jun 13 2018
Pages: 614
Weight: 2.92
Height: 1.50 Width: 7.39 Depth: 10.24
Language: English
Part I: Introduction to Teratology Testing
1. An Overview of Teratology
Ana M. Calado and Maria dos Anjos Pires
2. Teratology Study Guidelines: An Overview
Sofia Alves-Pimenta, Luís Félix, Bruno Colaço, Paula A. Oliveira, and Carlos Venâncio
3. Biological Concerns on the Selection of Animal Models for Teratogenic Testing
Sofia Alves-Pimenta, Bruno Colaço, Paula A. Oliveira, and Carlos Venâncio
Part II: In Vitro-Based Teratology Screening
4. The Validated Embryonic Stem Cell Test with Murine Embryonic Stem Cells
Lauren M. Walker, Darcie L.V. McClelland-Descalzo, and Nicole I. zur Nieden
5. Human Pluripotent Stem Cells to Assess Developmental Toxicity in the Osteogenic Lineage
Joseph V. Madrid, Steven R. Sera, Nicole R.L. Sparks, and Nicole I. zur Nieden
6. Chick Embryonic Cardiomyocytes Micromass System for Assessing Developmental Cardiotoxicity of Drugs
Wasay M.S. Qureshi and Margaret K. Pratten
7. Flow Cytometry to Evaluate Potential Developmental Toxicants in the Embryonic Stem Cell
Valéria Maria Lara, Kelly C. Santos Roballo, André Tadeu Gotardo, and Carlos Eduardo Ambrósio
8. Morphology-Based Whole Embryo Culture for Developmental Toxicity of Drugs
Bo Liang and Chi C. Wang
9. Western Blot Methodologies for Analysis of In Vitro Protein Expression Induced by Teratogenic Agents
Carlos Martins-Gomes and Amélia M. Silva
10. Manipulation of MicroRNAs in Cultured Mouse Embryos: Applications for Developmental Toxicology
Fuqiang Yuan and Shao-yu Chen
Part III: Animal-Based Teratology Methods
11. Insights into the Phenotypic and Behavioral Effects of Teratogenic Drugs in Caenorhabditis elegans
Caralina M. de Evsikova
12. Effect of Teratogens on Development of Drosophila melanogaster
Dong Li and Xiaolin Bi
13. Cellular Responses in Drosophila melanogaster Following Teratogen Exposure
Matheus C. Bianchini, José L.R. Portela, Robson L. Puntel, and Daiana S. Ávila
14. Behavioral Teratogenesis in Drosophila melanogaster
Monalisa Mishra and Bedanta Kumar Barik
15. Evaluation of the Teratogenicity of Pharmaceuticals Using FETAX
Hariz Islas-Flores, Itzayana Pérez-Alvaréz, and Leobardo M. Gómez-Oliván
16. Histological Observation of Teratogenic Phenotypes Induced in Frog Embryo Assays
&n
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