Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
The Role of Inflammation in Oral Carcinogenesis

The Role of Inflammation in Oral Carcinogenesis

Thomas, Priya
Mathew, Deepu George
Sunil, Shivani

Paperback

Medical Reference

ISBN10: 6630048237
ISBN13: 9786630048230
Publisher: LAP Lambert Academic Publishing
Published: Jun 5 2026
Pages: 188
Weight: 0.57
Height: 0.43 Width: 6.00 Depth: 9.00
Language: English
Inflammation plays a crucial role in oral carcinogenesis by creating a microenvironment that promotes the initiation, progression, and spread of cancer. Chronic inflammatory conditions lead to the continuous release of inflammatory cytokines, growth factors, reactive oxygen species (ROS), and reactive nitrogen species (RNS). These mediators cause DNA damage, genetic mutations, increased cellular proliferation, inhibition of apoptosis, angiogenesis, and immune evasion. Inflammatory cells such as macrophages, neutrophils, and lymphocytes further contribute to tumor development by secreting cytokines including TNF-α, IL-1, IL-6, and IL-8. Thus, persistent inflammation acts as a driving force in the multistep process of oral carcinogenesis and is now recognized as one of the hallmarks of cancer.

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