Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
612-822-4611

  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Repurposing Cardiac Glycosides: New Frontiers in Cancer Treatment

Repurposing Cardiac Glycosides: New Frontiers in Cancer Treatment

Macwan, Carol

Paperback

Medical Reference

ISBN10: 6209398901
ISBN13: 9786209398902
Publisher: LAP Lambert Academic Publishing
Published: Nov 30 2025
Pages: 88
Weight: 0.28
Height: 0.21 Width: 6.00 Depth: 9.00
Language: English
This book examines cardiac glycosides (CGs) as emerging multi-targeted anticancer agents. Beyond their traditional use in cardiology, CGs modulate Na⁺/K⁺-ATPase-linked signaling pathways that control cancer cell survival, apoptosis, autophagy, angiogenesis, and immune activation. The book highlights key mechanisms, including mitochondrial apoptosis, ROS generation, HIF-1α inhibition, and immunogenic cell death that enhances antitumor immunity. It summarizes strong preclinical evidence across major cancer types and outlines synergy with chemotherapy, targeted therapy, radiotherapy, and immunotherapy. Clinical findings are promising but limited by cardiotoxicity, narrow therapeutic index, pharmacokinetic variability, and tumor heterogeneity. The book explores innovative solutions-structure-activity optimization, isoform-selective analogues, nanoparticle delivery, tumor-activated prodrugs, AI-guided drug design, and biomarker-based patient selection-to improve safety and efficacy. It concludes that CGs hold significant potential as future precision oncology therapeutics.

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