Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
612-822-4611

  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Primary Progressive Multiple Sclerosis

Primary Progressive Multiple Sclerosis

Filippi, M.
Comi, G.

Paperback

Series: Topics in Neuroscience

Medical Reference

ISBN10: 8847022363
ISBN13: 9788847022362
Publisher: Springer Pg
Published: Mar 6 2012
Pages: 128
Weight: 0.45
Height: 0.30 Width: 6.14 Depth: 9.21
Language: English
Why are there no effective treatments for my condition? Why do researchers exclude patients with primary progressive multiple sclerosis from enrolling in clinical trials? Please let me know if you hear of studies that I might be allowed to enter or treatments that I could try for my condition. Thus, in recent years, the sad lament of the patient with primary progressive MS (PPMS). This variant, often in the guise of a chronic progressive myelopathy or, less commonly, progressive cerebellar or bulbar dysfunction, usually responds poorly to corticosteroids and rarely seems to benefit to a significant degree from intensive immunosuppressive treatments. In recent years, most randomized clin- ical trials have excluded PPMS patients on two counts. Clinical worsening devel- ops slowly in PPMS and may not be recognized during the course of a 2-or 3-year trial even in untreated control patients. This factor alone adds to the potential for a type 2 error or, at the very least, inflates the sample size and duration of the trial. In addition, there is mounting evidence that progressive axonal degeneration and neuronal loss (rather than active, recurrent inflammation) may be important components of the pathology in this form of the disease. Although contemporary trials are evaluating whether PPMS patients may benefit from treatment with the -interferons and glatiramer acetate, preliminary, uncontrolled clinical experi- ence suggests that the results may not be dramatic.

Also in

Medical Reference

View All