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612-822-4611
Preoperative Chemoradiation in locally advanced rectal cancer

Preoperative Chemoradiation in locally advanced rectal cancer

Paperback

Medical Reference

ISBN10: 6209266185
ISBN13: 9786209266188
Publisher: LAP Lambert Academic Publishing
Published: Mar 18 2026
Pages: 136
Weight: 0.42
Height: 0.32 Width: 6.00 Depth: 9.00
Language: English
This book explores the surgical and therapeutic challenges posed by locally advanced rectal cancers located below the anterior peritoneal reflection-a region historically associated with high relapse rates. It examines modern treatment standards, specifically preoperative chemoradiotherapy (CRT) with fluoropyrimidine, as recommended by the European Society for Medical Oncology (ESMO) guidelines. The text further evaluates phase II trials involving combination therapies with oxaliplatin or irinotecan, balancing enhanced tumor regression against increased toxicity profiles. By analyzing tumor downstaging, sphincter preservation, and overall survival rates, this book provides a comprehensive evaluation of clinical outcomes and the long-term impact on patient quality of life.

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Medical Reference