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Papel do polimorfismo dos genes CYP2A6 no tratamento da dependência da nicotina
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ISBN10: 6208173590
ISBN13: 9786208173593
Publisher: Edicoes Nosso Conhecimento
Published: Oct 9 2024
Pages: 80
Weight: 0.28
Height: 0.19 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786208173593
Publisher: Edicoes Nosso Conhecimento
Published: Oct 9 2024
Pages: 80
Weight: 0.28
Height: 0.19 Width: 6.00 Depth: 9.00
Language: Portuguese
Funcionalmente, os genes fornecem a informação que governa as actividades biológicas e fisiológicas básicas das células, condicionando o nosso comportamento em relação à s mudanças do nosso ambiente. As variantes do CYP2A6 inibem e reduzem de forma variável a dependência da nicotina e desempenham um papel importante na absorção, distribuição e eliminação da nicotina, o que implica o seu potencial clÃnico. Além disso, as variantes do CYP2A6 têm sido associadas ao comportamento tabágico, ao desenvolvimento da dependência da nicotina e ao tratamento em estudos epidemiológicos quantitativos e laboratoriais em seres humanos. No presente estudo, parece que as actividades enzimáticas das variantes do CYP2A6 estão correlacionadas com a variação dos comportamentos tabágicos e estão implicadas nos tratamentos com nicotina, uma vez que são capazes de metabolizar a nicotina, e na utilização de medicamentos no tratamento da dependência da nicotina.
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