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Rôle du polymorphisme des gènes CYP2A6 dans le traitement de la dépendance à la nicotine
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ISBN10: 6208173574
ISBN13: 9786208173579
Publisher: Editions Notre Savoir
Published: Oct 9 2024
Pages: 80
Weight: 0.28
Height: 0.19 Width: 6.00 Depth: 9.00
Language: French
ISBN13: 9786208173579
Publisher: Editions Notre Savoir
Published: Oct 9 2024
Pages: 80
Weight: 0.28
Height: 0.19 Width: 6.00 Depth: 9.00
Language: French
Sur le plan fonctionnel, les gènes fournissent les informations qui régissent les activités biologiques et physiologiques de base des cellules, conditionnant notre comportement en relation avec les changements de notre environnement. Les variantes du CYP2A6 inhibent et réduisent de manière variable la dépendance à la nicotine et jouent un rôle important dans l'absorption, la distribution et la clairance de la nicotine, ce qui implique leur potentiel clinique. En outre, les variantes de CYP2A6 ont été associées au comportement tabagique, au développement de la dépendance à la nicotine et au traitement dans des études épidémiologiques quantitatives et des études de laboratoire sur l'homme. Il ressort de cette étude que les activités enzymatiques des variantes de CYP2A6 sont corrélées à la variation des comportements tabagiques et sont impliquées dans les traitements à la nicotine car elles sont capables de métaboliser la nicotine, ainsi que dans l'utilisation de médicaments pour le traitement de la dépendance à la nicotine.
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