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Estado clÃnico-patológico e metilação do ADN do CCR no Bangladesh
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ISBN10: 620236453X
ISBN13: 9786202364539
Publisher: Edicoes Nosso Conhecimento
Published: Aug 8 2025
Pages: 84
Weight: 0.27
Height: 0.20 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786202364539
Publisher: Edicoes Nosso Conhecimento
Published: Aug 8 2025
Pages: 84
Weight: 0.27
Height: 0.20 Width: 6.00 Depth: 9.00
Language: Portuguese
O cancro colorretal (CCR) é o terceiro tipo de cancro mais comum no mundo e a segunda causa principal de morte por cancro nos Estados Unidos. Globalmente, a incidência do CCR varia muito. O risco de desenvolver CCR ao longo da vida é de cerca de 6% ou um em cada 18. O CCR é relativamente incomum no subcontinente indiano. A incidência de cancro colorretal em Bangladesh não é exatamente conhecida, mas parece ser comum e ocorrer em grupos etários mais jovens, com ligeira predominância masculina. A idade média no diagnóstico é 10 anos menor do que nos paÃses desenvolvidos. As alterações epigenéticas, que são alterações hereditárias na função dos genes que não se devem a alterações na sequência do ADN, são uma via importante no mecanismo de tumorigénese no cancro colorretal. As anomalias na metilação do ADN são alterações epigenéticas importantes no CCR e tornaram-se uma área de grande interesse no campo da investigação do cancro. Existem anomalias de hipermetilação e hipometilação em vários loci genéticos no CCR. A correlação das caracterÃsticas histopatológicas com os dados clÃnicos e a deteção de anomalias na metilação do ADN podem proporcionar uma melhor compreensão neste campo.
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