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Kliniczno-patologiczny i stan metylacji DNA w przypadku raka jelita grubego w Bangladeszu
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ISBN10: 6202364513
ISBN13: 9786202364515
Publisher: Wydawnictwo Nasza Wiedza
Published: Aug 8 2025
Pages: 84
Weight: 0.27
Height: 0.20 Width: 6.00 Depth: 9.00
Language: Polish
ISBN13: 9786202364515
Publisher: Wydawnictwo Nasza Wiedza
Published: Aug 8 2025
Pages: 84
Weight: 0.27
Height: 0.20 Width: 6.00 Depth: 9.00
Language: Polish
Rak jelita grubego (CRC) jest trzecim najczęściej występującym nowotworem na świecie i drugą najczęstszą przyczyną zgonów z powodu nowotworów w Stanach Zjednoczonych. Na calym świecie częstośc występowania CRC jest bardzo zróżnicowana. Ryzyko zachorowania na CRC w ciągu calego życia wynosi okolo 6% lub jeden na 18 osób. CRC występuje stosunkowo rzadko na subkontynencie indyjskim. Częstośc występowania raka jelita grubego w Bangladeszu nie jest dokladnie znana, ale wydaje się, że jest to nowotwór powszechny, występujący w mlodszej grupie wiekowej, z niewielką przewagą mężczyzn. Średni wiek rozpoznania wynosi 10 lat mniej niż w krajach rozwiniętych. Zmiany epigenetyczne, czyli dziedziczne zmiany funkcji genów, które nie są spowodowane zmianami w sekwencji DNA, są ważnym szlakiem w mechanizmie powstawania nowotworów jelita grubego. Nieprawidlowości metylacji DNA są ważnymi zmianami epigenetycznymi w CRC i stanowią obszar dużego zainteresowania w dziedzinie badań nad rakiem. W CRC występują zarówno nieprawidlowości hipermetylacji, jak i hipometylacji w różnych loci genetycznych. Korelacja cech histopatologicznych z danymi klinicznymi i wykrywanie nieprawidlowości metylacji DNA może zapewnic lepszy wgląd w tę dziedzinę.
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