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Diagnóstico com microARN nas doenças renais: inovações e desafios
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ISBN10: 6630328108
ISBN13: 9786630328103
Publisher: Edicoes Nosso Conhecimento
Published: Jul 22 2026
Pages: 64
Weight: 0.22
Height: 0.15 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786630328103
Publisher: Edicoes Nosso Conhecimento
Published: Jul 22 2026
Pages: 64
Weight: 0.22
Height: 0.15 Width: 6.00 Depth: 9.00
Language: Portuguese
A doença renal crónica (DRC) constitui um problema de saúde global substancial, afetando mais de 850 milhões de pessoas em todo o mundo. Os biomarcadores clÃnicos atuais não possuem sensibilidade suficiente para identificar lesões renais precoces. Os pequenos ARNs não codificantes (ncRNAs) têm vindo a suscitar cada vez mais atenção como biomarcadores promissores para o diagnóstico precoce e a orientação terapêutica da DRC. Os microARN são moléculas curtas de ARN não codificante que modulam a expressão génica. Devido à sua notável estabilidade nos fluidos biológicos, os microARN podem ser detetados e quantificados de forma fiável, o que realça o seu potencial como biomarcadores prognósticos e de diagnóstico e como alvos terapêuticos. A expressão anómala de microARN tem sido apontada como um fator determinante no inÃcio e na progressão de inúmeras doenças humanas complexas, incluindo as doenças renais. Evidências crescentes indicam que os miARN podem servir como alvos viáveis para a criação de novas abordagens terapêuticas para a DRC. Assim, este livro apresenta os conhecimentos atuais sobre a importância dos miARN no diagnóstico precoce e na intervenção na DRC, abordando também os principais desafios e as orientações futuras no desenvolvimento de terapêuticas baseadas em miARN para o tratamento da DRC.
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