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Le diagnostic par microARN dans les maladies rénales: innovations et défis
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ISBN10: 6630320425
ISBN13: 9786630320428
Publisher: Editions Notre Savoir
Published: Jul 23 2026
Pages: 64
Weight: 0.22
Height: 0.15 Width: 6.00 Depth: 9.00
Language: French
ISBN13: 9786630320428
Publisher: Editions Notre Savoir
Published: Jul 23 2026
Pages: 64
Weight: 0.22
Height: 0.15 Width: 6.00 Depth: 9.00
Language: French
La maladie rénale chronique (MRC) constitue un problème de santé majeur à l'échelle mondiale, touchant plus de 850 millions de personnes dans le monde. Les biomarqueurs cliniques actuels ne présentent pas une sensibilité suffisante pour détecter précocement une atteinte rénale. Les petits ARN non codants (ARNnc) suscitent un intérêt croissant en tant que biomarqueurs prometteurs pour le diagnostic précoce et le ciblage thérapeutique de l'IRC. Les microARN sont de courtes molécules d'ARNnc qui modulent l'expression génique. Grâce à leur remarquable stabilité dans les liquides biologiques, les microARN peuvent être détectés et quantifiés de manière fiable, ce qui met en évidence leur potentiel en tant que biomarqueurs pronostiques et diagnostiques, ainsi qu'en tant que cibles thérapeutiques. Une expression anormale des miARN a été identifiée comme un facteur déterminant dans l'apparition et la progression de nombreuses pathologies humaines complexes, notamment les maladies rénales. Des preuves de plus en plus nombreuses indiquent que les miARN pourraient constituer des cibles viables pour la mise au point de nouvelles approches thérapeutiques de l'IRC. En conséquence, cet ouvrage présente les connaissances actuelles concernant l'importance des miARN dans le diagnostic précoce et l'intervention précoce de l'IRC, tout en abordant les principaux défis et les orientations futures dans le développement de traitements basés sur les miARN pour la prise en charge de l'IRC.
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