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Mikrośrodowisko komórek macierzystych i jego wplyw na leczenie bialaczki
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ISBN10: 6209850413
ISBN13: 9786209850417
Publisher: Wydawnictwo Nasza Wiedza
Published: Mar 31 2026
Pages: 140
Weight: 0.43
Height: 0.33 Width: 6.00 Depth: 9.00
Language: Polish
ISBN13: 9786209850417
Publisher: Wydawnictwo Nasza Wiedza
Published: Mar 31 2026
Pages: 140
Weight: 0.43
Height: 0.33 Width: 6.00 Depth: 9.00
Language: Polish
Ostra bialaczka limfoblastyczna jest jedną z najczęstszych postaci bialaczki występujących u dzieci. Chociaż odnotowano znaczny postęp w zakresie wskaźnika wyleczeń, nadal pewien odsetek dzieci jest narażony na ryzyko zgonu z powodu oporności na leki lub toksycznych skutków ubocznych terapii. Glukokortykoidy, takie jak deksametazon, są regularnie stosowane w leczeniu ze względu na ich dzialanie proapoptotyczne. Najnowsze badania podkreślają rolę komórek macierzystych szpiku kostnego w rozwoju oporności i niepowodzeniu leczenia, a w konsekwencji w zgonie pacjenta. W niniejszej książce wykazaliśmy, jak ważne jest uwzględnienie różnic między leczeniem skojarzonym a leczeniem pojedynczym oraz wplywu komórek macierzystych szpiku kostnego na opornośc na leki. Podsumowując, nasze odkrycia mogą przyczynic się do lepszego zrozumienia biologicznych i molekularnych aspektów różnic między komórkami wrażliwymi i opornymi w ostrej bialaczce limfoblastycznej oraz wplywu niszy komórek macierzystych na terapię, co może przyczynic się do opracowania skuteczniejszych i mniej toksycznych metod leczenia.
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