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Das Mikroumfeld von Stammzellen und seine Auswirkungen auf die Behandlung von Leukämie
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ISBN10: 6209829937
ISBN13: 9786209829932
Publisher: Verlag Unser Wissen
Published: Mar 31 2026
Pages: 144
Weight: 0.44
Height: 0.34 Width: 6.00 Depth: 9.00
Language: German
ISBN13: 9786209829932
Publisher: Verlag Unser Wissen
Published: Mar 31 2026
Pages: 144
Weight: 0.44
Height: 0.34 Width: 6.00 Depth: 9.00
Language: German
Die akute lymphoblastische Leukämie ist eine der häufigsten Formen der Leukämie bei Kindern. Obwohl bei der Heilungsrate bemerkenswerte Fortschritte erzielt wurden, besteht für einen Teil der Kinder nach wie vor das Risiko, aufgrund von Arzneimittelresistenzen oder toxischen Nebenwirkungen der Behandlung zu sterben. Glukokortikoide wie Dexamethason werden aufgrund ihrer proapoptotischen Wirkung regelmä ig in der Behandlung eingesetzt. Jüngste Studien haben die Rolle von Knochenmarkstammzellen bei der Entwicklung von Resistenzen, dem Versagen der Behandlung und dem daraus resultierenden Tod des Patienten hervorgehoben. In diesem Buch haben wir aufgezeigt, wie wichtig es ist, zu berücksichtigen, inwiefern sich eine kombinierte medikamentöse Behandlung von einer Einzelmedikamententherapie unterscheidet und wie die Knochenmarkstammzellen die Arzneimittelresistenz beeinflussen können. Zusammenfassend lässt sich sagen, dass unsere Erkenntnisse das Verständnis der biologischen und molekularen Aspekte der Unterschiede zwischen empfindlichen und resistenten Zellen bei der akuten lymphoblastischen Leukämie sowie der Wirkung der Stammzellnische auf die Therapie verbessern können, was zu einer effizienteren und weniger toxischen Therapie beitragen kann.
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