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    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

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Pathogenesis of Shigellosis

Pathogenesis of Shigellosis

Sansonetti, P. J.

Paperback

Series: Current Topics in Microbiology and Immmunology, Book 180

Medical ReferenceEvolution

ISBN10: 3642772404
ISBN13: 9783642772405
Publisher: Springer Nature
Published: Dec 16 2011
Pages: 143
Weight: 0.51
Height: 0.34 Width: 6.14 Depth: 9.21
Language: English
Shigellosis is present all over the world. Anyone traveling in developing countries knows that the control of this invasive disease of the intestine is a priority task for physicians and public health authorities. Victims are essentially young children, and complications such as the hemolytic uremic syndrome make shigellosis a systemic disease rather than simply an infection of the colonic mucosa. However, Westerners should not consider shigeJlosis as an unlikely threat of the tropics. The disease arises in industrialized countries as soon as breaches in sanitation appear. A few months ago, at least 500 people developed shigellosis in northern France in an outbreak of Shigella sonnei infection due to accidental contamination of an urban water delivery system. The pathogenesis of shigellosis is an extraordinary topic of research because study of the invasion of the colonic mucosa addresses fundamental questions on. the molecular and cellular mechanisms by which a bacterial pathogen can pene- trate non phagocytic cells, survive, multiply, spread in the intra- cellular compartment, and eventually kill host cells. Further development of the infection within subepithelial tissues as well as the mechanisms that contribute to the eradication of this process have barely been studied.

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