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Oral Bioavailability Assessment
Hardcover
Series: Wiley Pharmaceutical Science and Biotechnology: Practices, Applications and Methods
ISBN13: 9781118916698
Publisher: Wiley
Published: Jun 6 2017
Pages: 448
Weight: 1.70
Height: 1.10 Width: 6.20 Depth: 9.30
Language: English
- Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability
- Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development
- Explains how preclinical animal models - used in preclinical testing - and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development
- Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)
- Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development
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