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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Mitochondrial DNA abnormalities in patients with idiopathic myositis

Mitochondrial DNA abnormalities in patients with idiopathic myositis

Joshi, Pushpa Raj

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Medical Reference

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ISBN10: 3838133765
ISBN13: 9783838133768
Publisher: Sudwestdeutscher Verlag Fur Ho
Published: Oct 9 2012
Pages: 132
Weight: 0.45
Height: 0.31 Width: 6.00 Depth: 9.00
Language: English
Mitochondrial DNA deletions are seen in patients with different forms of myositis, being most prominent in inclusion body myositis (IBM). However, the level of common deletion in myositis is very small. Real-time PCR analysis is the ideal method to quantify very less levels of deletion with higher sensitivity. Histologically, COX deficient muscle fibres and ragged-red muscle fibres are seen in patients with all three forms of myositis. Hence, these mitochondrial defects could be considered as precursors of pathogenesis in myositis. Multiple-cell real-time PCR analysis detected common deletion in both normal and COX negative fibres. Genarally, the degree of presence of common deletion in a fibre to become COX negative is roughly 80%, suggesting the argument that mitochondrial protein synthesis is impaired when a particular percentage of deletions in mtDNA is reached. However, the high levels of deletions in mtDNA alone do not seem to cause a severe COX deficiency and/or residual COX deficiency. Hence the defect in mitochondrial protein synthesis is predominantly by the reduction of wild-type mtDNA in affected cells.

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