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Insilico Docking Against Breast Cancer using Rhinacanthone

Insilico Docking Against Breast Cancer using Rhinacanthone

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Medical Reference

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ISBN10: 3659185507
ISBN13: 9783659185502
Publisher: Lap Lambert Academic Pub
Published: Aug 1 2012
Pages: 124
Weight: 0.42
Height: 0.29 Width: 6.00 Depth: 9.00
Language: English
The drug-likeness and efficiency of various herbal compounds were screened by docking studies. One of the main pharmacological problems today in the treatment of cancer consists of the fact that anti-inflammatory drugs usually exhibit side effects. The natural products offer a great hope in the identification of bioactive lead compounds and their development into drugs for treating inflammatory diseases. Computer-aided drug design has proved to be a very useful tool for discovering new drugs. Rhinacanthus nasutus is an important medicinal plant which possess bioactive compound RhinacanthoneIn this work an attempt was made to dock the target proteins of breast cancer with rhinacanthone and the plant genome was annotated using various bioinformatics software tools to decipher the biological functions of various proteins present in it.Rhinacanthone was found to have best interaction with BRCA1 target protein. Thus this small molecule Rhinacanthone is suggested to be used clinically as anti tumor agent.

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