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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Critical Care Toxicology Handbook: Toxidrome Recognition, Antidote Selection, and Organ-Directed Management of the Poisoned Patient

Critical Care Toxicology Handbook: Toxidrome Recognition, Antidote Selection, and Organ-Directed Management of the Poisoned Patient

Bazan, Danielle J.

Paperback

Medical Reference

Currently unavailable to order

ISBN13: 9798192071700
Publisher: Independently Published
Pages: 416
Weight: 2.11
Height: 0.85 Width: 8.50 Depth: 11.00
Language: English
The patient arrives at three in the morning. No history. No witness. An empty blister pack and a heart rate you cannot explain.

What do you do in the next fifteen minutes?

Can you separate an anticholinergic delirium from a sympathomimetic one before the laboratory calls back? Do you know which poisonings dialysis can actually reach and which ones it cannot touch no matter how sick the patient is? When the urine drug screen says amfetamines and the patient says otherwise, which one do you believe?

This is a bedside reference for clinicians managing poisoned and overdosed patients in the emergency department and intensive care unit. It is built around a single organising idea: identify the failure mode before you identify the agent.

What this handbook gives you

  • A five-second bedside discrimination. Dry skin with a silent abdomen separates anticholinergic from sympathomimetic toxicity and only one of those patients can still lose heat. Six core toxidromes, separable with no laboratory input at all.
  • The four numbers that decide everything. Volume of distribution, protein binding, molecular weight and endogenous clearance determine whether any intervention you possess can reach the drug. Sixteen agents plotted against the removable zone.
  • Honest limits on the tests you order. Which immunoassay windows produce false positives, which classes they miss entirely, and why a negative opiate screen in a patient with pinpoint pupils is a limitation of the assay rather than a refutation of the diagnosis.
  • What to withhold, and why. Gastric lavage, ipecac, flumazenil in mixed ingestion, phenytoin for a toxic seizure, amiodarone in channel blockade, nitrite kits in fire victims each contraindication with the mechanism behind it.
  • Antidote dosing that is escalated, not looked up. Atropine titrated to drying secretions with no ceiling. Naloxone infusions calculated from the cumulative effective dose. Digoxin antibody fragments by two formulae that give four-fold different answers.
  • 45 worked clinical scenarios carrying the arithmetic through to a number bicarbonate volumes, insulin units, ethanol blockade rates, gap calculations, pyridoxine in grams.
  • 60 original diagrams: the cardiac action potential mapped to its four toxicological targets, cholinesterase ageing, paraquat redox cycling, the two gaps plotted over time.
  • 105 practice questions with boxed reasoning, not just answers.
Why it is organised this way
  • Toxicology is a field where confident bedside teaching frequently outruns the data. This book distinguishes three things that are routinely conflated: an adequately powered negative finding, an underpowered one, and the genuine absence of evidence. Where trials conflict hyperbaric oxygen in carbon monoxide poisoning, oximes in organophosphate poisoning the disagreement is described rather than smoothed over. Every drug dose appears as a range with an instruction to verify against your local formulary.
  • Written for
  • Emergency physicians, intensivists, anaesthetists, clinical pharmacists, advanced practice providers, critical care nurses and senior trainees. Resuscitation, ventilation and acid-base interpretation are assumed; toxicology is taught from first principles.
  • Fifteen chapters across five parts foundations of the poisoned patient, core interventions, organ-directed toxicity, major agent classes, and special populations with disposition.
  • This is an independent work. It supplements, and does not replace, your primary toxicology text, your national poisons centre or the guideline in force where you practise.

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