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The P53 Protein: From Cell Regulation to Cancer
Hardcover
Medical ReferenceBiologyChemistry
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ISBN13: 9781621821335
Publisher: Cold Spring Harbor Laboratory Press
Published: Mar 31 2016
Pages: 504
Weight: 3.10
Height: 1.10 Width: 7.20 Depth: 10.20
Language: English
in-and sometimes even promotes-human cancer. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the rapid progress that has recently been made in basic and clinical research on p53. The contributors review new observations about its basic biology, providing updates on the
cancer, exploring the various inherited and somatic mutations in the human TP53 gene, the impact of mutant p53 proteins on tumorigenesis, and the prognostic value and clinical outcomes of these mutations. Drugs that are being developed to respond to tumors harboring aberrant p53 are also described. This book is therefore essential reading for all cancer biologists, cell and molecular biologists, and pharmacologists concerned with the treatment of this disease.
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