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Some Thyrotropic Agents

Some Thyrotropic Agents

Paperback

Series: IARC Monographs on the Evaluation of the Carcinogenic Risks, Book 76

Medical ReferenceCancer

ISBN10: 9283212797
ISBN13: 9789283212799
Publisher: World Health Organization
Published: Nov 1 2001
Pages: 763
Weight: 2.91
Height: 1.54 Width: 7.00 Depth: 10.00
Language: English
This volume evaluates carcinogenicity to humans of 19 chemicals that are carcinogenic to the thyroid follicular-cell epithelium in rodents. These included some so-called anti-thyroid drugs (methimazole, methylthiouracil, propylthiou-racil and thiouracil); some sedatives (doxylamine succinate and phenobarbital); and some other drugs including the systemic antifungal antibiotic griseofulvin, the diuretic spironolactone, and the antibacterial sulfa drugs sulfamethazine and sulfamethoxazole. Other chemicals are or have been used in agriculture as pesticides (amitrole, chlordane/heptachlor, hexachlo-robenzene and toxaphene), in foods and cosmetics (kojic acid), in hair dyes (2 4-diaminoanisole) or as industrial chemicals (N N'-diethylthiourea, ethylenethiourea and thiourea).

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