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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Sample Size Determination in Clinical Trials with Multiple Endpoints

Sample Size Determination in Clinical Trials with Multiple Endpoints

Sozu, Takashi
Sugimoto, Tomoyuki
Hamasaki, Toshimitsu

Paperback

Series: Springerbriefs in Statistics

Medical ReferenceGeneral ScienceProbability & Statistics

ISBN10: 3319220047
ISBN13: 9783319220048
Publisher: Springer Nature
Published: Sep 4 2015
Pages: 95
Weight: 0.35
Height: 0.22 Width: 6.14 Depth: 9.21
Language: English

This book integrates recent methodological developments for calculating the sample size and power in trials with more than one endpoint considered as multiple primary or co-primary, offering an important reference work for statisticians working in this area.

The determination of sample size and the evaluation of power are fundamental and critical elements in the design of clinical trials. If the sample size is too small, important effects may go unnoticed; if the sample size is too large, it represents a waste of resources and unethically puts more participants at risk than necessary. Recently many clinical trials have been designed with more than one endpoint considered as multiple primary or co-primary, creating a need for new approaches to the design and analysis of these clinical trials. The book focuses on the evaluation of power and sample size determination when comparing the effects of two interventions in superiority clinical trials with multiple endpoints. Methods for sample size calculation in clinical trials where the alternative hypothesis is that there are effects on ALL endpoints are discussed in detail. The book also briefly examines trials designed with an alternative hypothesis of an effect on AT LEAST ONE endpoint with a prespecified non-ordering of endpoints.

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