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Molekulyarnye Aspekty Razvitiya Papillyarnykh Kartsinom Shchitovidnoy Zhelezy
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ISBN10: 3639819535
ISBN13: 9783639819533
Publisher: Blues Kids Of Amer
Published: Mar 28 2014
Pages: 168
Weight: 0.56
Height: 0.39 Width: 6.00 Depth: 9.00
Language: Russian
ISBN13: 9783639819533
Publisher: Blues Kids Of Amer
Published: Mar 28 2014
Pages: 168
Weight: 0.56
Height: 0.39 Width: 6.00 Depth: 9.00
Language: Russian
V rabote rassmotreny molekulyarnye aspekty razvitiya i formirovaniya fenotipa papillyarnykh kartsinom shchitovidnoy zhelezy. Privedeny dannye o raznykh geneticheskikh narusheniyakh (tochechnykh mutatsiyakh i strukturnykh perestroykakh), kotorye identifitsirovany v dannykh opukholyakh, ikh chastote, spetsifichnosti, a takzhe faktorakh, privodyashchikh k generatsii takikh onkogenov v tireoidnykh kletkakh. Obsuzhdeny mekhanizmy vliyaniya onkogenov na protsessy transduktsii vnutrikletochnykh signalov, ekspressiyu tireoidspetsificheskikh belkov i transkriptsionnuyu aktivnost' retseptornykh tirozinkinaz. Osoboe vnimanie pri etom udeleno razlichiyam realizatsii onkogennykh effektov v dobrokachestvennykh i zlokachestvennykh opukholyakh shchitovidnoy zhelezy. Zatronuty sovremennye napravleniya razvitiya targetnoy terapii differentsirovannogo raka shchitovidnoy zhelezy i potentsial'nye vozmozhnosti primeneniya molekulyarno-biologicheskikh issledovaniy pri razrabotke metodov takogo lecheniya. Proanalizirovany dannye o chastote, formakh i mekhanizmakh vozmozhnogo vliyaniya razlichnykh patologicheskikh protsessov v shchitovidnoy zheleze na fenotip papillyarnogo raka. Ochercheny aktual'nye napravleniya sovremennykh issledovaniy i predstavleny potentsial'nye algoritmy ikh realizatsii.
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