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The Respiratory Burst and Its Physiological Significance

The Respiratory Burst and Its Physiological Significance

Paperback

Medical ReferenceChemistryGeneral Gardening

ISBN10: 1468454986
ISBN13: 9781468454987
Publisher: Springer Nature
Published: Mar 4 2012
Pages: 500
Weight: 1.47
Height: 1.01 Width: 6.00 Depth: 9.00
Language: English
When phagocytes are exposed to a number of different stimuli, they undergo dra- matic changes in the way they process oxygen. Oxygen uptake increases markedly, frequently more than 50-fold; the phagocytes begin to produce large quantities of superoxide and hydrogen peroxide; and they immediately begin to metabolize large amounts of glucose by way of the hexose monophosphate shunt. This series of changes has become known as the respiratory burst. It was first believed that the major function of this respiratory burst was to generate powerful antibacterial agents by the partial reduction of oxygen. It is becoming apparent that the respiratory burst has much wider application, and its physiological function in many different biolog- ical areas is clear. In this volume, we have attempted to bring together the work of experts who have published extensively on the involvement of the respiratory burst in different physiological functions. In the first three chapters, Dr. Borregaard and Dr. Berton and co-workers and Dr. Roos and co-workers bring together what is known about the respiratory burst. They present up-to-date versions of the biochemical and metabolic activities associ- ated with the burst. In Chapter 4, Dr. Styrt and Dr. Klempner discuss the respiratory burst as it affects cellular ion homeostasis. Dr. Cohen and Dr. Britigan (Chapter 5) present some interesting data on the competition between the respiratory burst and bacteria for oxygen. Dr. Dobrina and Dr.

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