Re-Evaluation of Drinking-Water Guidelines for Diisopropyl Methylphosphonate

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ISBN10: 0309072557
ISBN13: 9780309072557
Publisher: Natl Academy Pr
Published: Nov 25 2000
Pages: 48
Language: English

Diisopropyl Methylphosphonate (DIMP) is a groundwater contaminant at the U.S. Army's Rocky Mountain Arsenal in Colorado. DIMP is a by-product created from the manufacture and detoxification of the nerve agent GB which the arsenal produced from 1953 to 1957. For awhile the Army and the State of Colorado disagreed upon the appropriate drinking-water contaminant guideline for DIMP. A drinking-water guideline of 600 micrograms per liter was established by the U.S. Environmental Protection Agency (EPA) in 1989 but the State of Colorado promulgated a lower guideline of 8 micrograms per liter. The significant difference between the two suggested values arose from the fact that both sides used different studies to determine their values. Colorado used one-generation reproductive toxicity study in mink, whereas EPA used a subchronic toxicity study in dogs.

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