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Proteases: Structure and Function
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ISBN13: 9783709119396
Publisher: Springer
Published: Aug 23 2016
Pages: 564
Weight: 1.76
Height: 1.17 Width: 6.10 Depth: 9.25
Language: English
1 Protease families, evolution and mechanisms of action Set the stage.- 1.1 Enzyme families, prototypes and catalytic mechanisms.- 1.2 Enzyme kinetics, mathematical modelling and perspectives.- 1.3 Structure determination and search for inhibitors.- 2 Regulation of proteolysis Positioning and teaming-up to control activity.- 2.1 Compartmentalization of proteolysis.- 2.2 Biosynthesis of lysosomal proteases.- 2.3 Interactions of proteases and inhibitors / networking in the degradome.- 2.4 In vivo analysis of the protease and inhibitors concert.- 3 Proteases in development Born to be right.- 3.1 Proteases for pattern formation during morphogenesis.- 3.2 Proteases in death pathways (apoptosis, necrosis).- 4 Proteases in physiology and pathophysiology Cleave to function in health or to cause disease.- 4.1 Protein turnover and signaling functions (degrade to rebuild, remodel, process and mature for signalling).- 4.2 Proteases in control of physiology.- 4.3 Cancer: invasion and metastasis.- 4.4 Bacterial proteases.- 4.5 Viral proteases.
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