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Phenotypes and Genotypes: The Search for Influential Genes
Hardcover
Series: Computational Biology, Book 18
Medical ReferenceGeneral ScienceGenetics
ISBN13: 9781447153092
Publisher: Springer Nature
Published: Feb 24 2016
Pages: 222
Weight: 1.12
Height: 0.56 Width: 6.14 Depth: 9.21
Language: English
This timely text presents a comprehensive guide to genetic association, a new and rapidly expanding field that aims to elucidate how our genetic code (genotypes) influences the traits we possess (phenotypes). The book provides a detailed review of methods of gene mapping used in association with experimental crosses, as well as genome-wide association studies. Emphasis is placed on model selection procedures for analyzing data from large-scale genome scans based on specifically designed modifications of the Bayesian information criterion. Features: presents a thorough introduction to the theoretical background to studies of genetic association (both genetic and statistical); reviews the latest advances in the field; illustrates the properties of methods for mapping quantitative trait loci using computer simulations and the analysis of real data; discusses open challenges; includes an extensive statistical appendix as a reference for those who are not totally familiar with the fundamentals of statistics.
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