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Os Pecados dos Genes
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ISBN10: 6208097568
ISBN13: 9786208097561
Publisher: Edicoes Nosso Conhecimento
Published: Sep 18 2024
Pages: 64
Weight: 0.23
Height: 0.15 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786208097561
Publisher: Edicoes Nosso Conhecimento
Published: Sep 18 2024
Pages: 64
Weight: 0.23
Height: 0.15 Width: 6.00 Depth: 9.00
Language: Portuguese
Atualmente, o cancro da mama é o cancro mais comum entre as mulheres e é responsável por 25% de todos os cancros nas mulheres. A telomerase é um alvo terapêutico anticancerÃgeno adequado porque está presente em mais de 90% dos cancros humanos, incluindo mais de 95% dos cancros da mama, enquanto na maioria das células somáticas não é detetável. A proteÃna hTERT é um componente do complexo telomerase limitador da taxa, pelo que a expressão do gene hTERT no interior das células é essencial para a ativação da telomerase. Os miRNAs são um grupo de pequenos RNAs não codificantes com um comprimento de 25-19 nucleótidos que desempenham um papel fundamental como reguladores da expressão genética. As mulheres cuja mãe foi diagnosticada antes dos 50 anos têm um risco acrescido de 1,7 e aquelas cuja mãe foi diagnosticada aos 50 anos ou depois têm um risco acrescido de 1,4. Nas pessoas com zero, um ou dois familiares afectados, o risco de cancro da mama antes dos 80 anos é de 7,8%, 13,3% e 21,1%, com uma mortalidade subsequente da doença de 2,3%, 4,2% e 7,6%, respetivamente.
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