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O Fator 5 de Leiden dos polimorfismos genéticos como doença cardiovascular
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ISBN10: 6630146646
ISBN13: 9786630146646
Publisher: Edicoes Nosso Conhecimento
Published: Jun 16 2026
Pages: 60
Weight: 0.21
Height: 0.14 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786630146646
Publisher: Edicoes Nosso Conhecimento
Published: Jun 16 2026
Pages: 60
Weight: 0.21
Height: 0.14 Width: 6.00 Depth: 9.00
Language: Portuguese
Neste estudo, foram avaliadas 208 pessoas sem sintomas clÃnicos de doença cardÃaca - com antecedentes de doenças cardiovasculares e trombose venosa - na cidade de Tabriz, por diferentes grupos étnicos. Para avaliar a distribuição do polimorfismo do fator 5 de Leiden, uma doença genética associada a doenças cardiovasculares (DCV), na cidade de Tabriz, foi utilizado o método de hibridização reversa para um diagnóstico rápido e preciso. No âmbito das experiências de PCR multiplex e hibridização na tira de teste, as sondas de oligonucleótidos continham linhas paralelas especÃficas para cada alelo. A taxa de mutação do fator 5 de Leiden (1/2 %) na população do estudo foi inferior aos valores anteriormente publicados em Teerão (2/7 %), respetivamente. Neste estudo, foi analisada a distribuição dos alelos mutantes do fator 5 de Leiden na população da cidade de Tabriz. Os resultados foram comparados com os de outros estudos. Este é o estudo mais abrangente realizado até à data sobre o polimorfismo do gene do fator 5 de Leiden na cidade.
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