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Modelos roedores da perturbação do espetro do autismo: pontos fortes e limitações
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ISBN10: 6208600480
ISBN13: 9786208600488
Publisher: Edicoes Nosso Conhecimento
Published: Jan 28 2025
Pages: 68
Weight: 0.23
Height: 0.16 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786208600488
Publisher: Edicoes Nosso Conhecimento
Published: Jan 28 2025
Pages: 68
Weight: 0.23
Height: 0.16 Width: 6.00 Depth: 9.00
Language: Portuguese
A Perturbação do Espectro do Autismo (PEA) é uma doença psiquiátrica que resulta de uma interação complexa entre factores genéticos e ambientais. Os modelos animais têm sido utilizados para compreender a etiologia da perturbação, para encontrar um padrão de referência para o diagnóstico e para procurar tratamentos. Neste livro, os modelos de roedores para as PEA são objeto de uma análise crÃtica quanto à sua utilização para imitar a complexidade da biologia do desenvolvimento da perturbação. A sua validade é avaliada, bem como os ensaios de fenotipagem comportamental aplicados. As direcções futuras apontam para uma abordagem multi-modelo, em que o corpo como um sistema funcional é realçado. Os modelos animais são sempre um compromisso entre a imitação da complexidade da doença real e a conceção de experiências práticas. No entanto, estas experiências devem ser concebidas de forma a que o animal seja minimamente limitado na execução do seu comportamento natural. Combinando conhecimentos, reduzimos o funil em direção não só a um modelo de referência, mas também a uma estratégia de fenotipagem comportamental de referência, aumentando assim a capacidade de tradução do modelo animal.
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