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Modelli roditori del disturbo dello spettro autistico: punti di forza e limiti
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ISBN10: 6208600464
ISBN13: 9786208600464
Publisher: Edizioni Sapienza
Published: Jan 28 2025
Pages: 64
Weight: 0.22
Height: 0.15 Width: 6.00 Depth: 9.00
Language: Italian
ISBN13: 9786208600464
Publisher: Edizioni Sapienza
Published: Jan 28 2025
Pages: 64
Weight: 0.22
Height: 0.15 Width: 6.00 Depth: 9.00
Language: Italian
Il disturbo dello spettro autistico (ASD) è una malattia psichiatrica che deriva da una complessa interazione tra background genetico e ambientale. I modelli animali sono stati utilizzati per comprendere l'eziologia del disturbo, per trovare un gold standard per la diagnosi e per cercare trattamenti. In questo libro, i modelli di roditori per l'ASD sono esaminati criticamente per il loro utilizzo per imitare la complessità della biologia dello sviluppo del disturbo. Viene valutata la loro validità e i saggi di fenotipizzazione comportamentale applicati. Le direzioni future puntano verso un approccio multi-modello, in cui viene enfatizzato il corpo come un unico sistema funzionante. I modelli animali sono sempre un compromesso tra l'imitazione della complessità del disturbo reale e la progettazione di esperimenti pratici. Tuttavia, questi esperimenti dovrebbero essere progettati in modo tale che l'animale sia minimamente limitato nell'esecuzione del suo comportamento naturale. Combinando le conoscenze, restringiamo l'imbuto verso non solo un modello gold standard, ma anche una strategia di fenotipizzazione comportamentale gold standard, aumentando così la capacità traslazionale del modello animale.
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